## Denatured molecules

Vlassara, H., Uribarri, J. Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both? (2014) : https://doi.org/10.1007/s11892-013-0453-1

Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice (2019) : https://doi.org/10.1155/2019/2746521

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts (1998) : https://doi.org/10.1007/s007020050069

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals (2011) : https://doi.org/10.1016/j.mad.2011.10.007

Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects (2020) : https://doi.org/10.1155/2020/3818196

Ageing, age-related diseases and oxidative stress: What to do next? (2019) : https://doi.org/10.1016/j.arr.2019.100982

Advanced Glycation End Products and Risks for Chronic Diseases: Intervening Through Lifestyle Modification (2017) : https://doi.org/10.1177/1559827617708991

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease (2017) : https://doi.org/10.3390%2Fnu9040385

Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects (2020) : https://doi.org/10.1155/2020/3818196

Dietary advanced glycation end-products: Perspectives linking food processing with health implications (2020) : https://doi.org/10.1111/1541-4337.12593

The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension (2006) : https://pubmed.ncbi.nlm.nih.gov/16997053/

Potential reactions of thermal process contaminants during digestion (2020) : https://sciencedirect.com/science/article/abs/pii/S0924224420306373?via%3Dihub

Impact of telomere attrition on diabetes mellitus and its complications (2023) : https://doi.org/10.1016/j.deman.2023.100174

Shorter Telomere Length in Carriers of APOE-ε4 and High Plasma Concentration of Glucose, Glyoxal and Other Advanced Glycation End Products (AGEs) (2020) : https://doi.org/10.1093/gerona/glz203

Dietary Advanced Glycation End products interacting with the intestinal epithelium: What do we really know? (2023) : https://sciencedirect.com/science/article/pii/S2212877823000686#bib6

Tissue-resident memory T cells populate the human brain (2018) : https://doi.org/10.1038/s41467-018-07053-9

Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet (2010) : https://doi.org/10.1016/j.jada.2010.03.018

 

#### Meat

Evolution of the Human Life (2020) : https://doi.org/10.1017/9781108379977.005

On the evidence for human use and control of fire at Schöningen (2015) : https://sciencedirect.com/science/article/abs/pii/S0047248415000858

How Did Hominins Adapt to Ice Age Europe without Fire? (2017) : https://core.ac.uk/download/365177119.pdf

Evidence for adolescent length growth spurts in bonobos and other primates highlights the importance of scaling laws (2023) : https://doi.org/10.7554/eLife.86635.3

The evolution of the adolescent growth spurt: Urinary biomarkers of bone turnover in wild chimpanzees (Pan troglodytes) (2023) : https://doi.org/10.1016/j.jhevol.2023.103341

Ages at menopause and menarche in a high-altitude Himalayan population (1983) : https://pubmed.ncbi.nlm.nih.gov/6614862/

In Vitro Fertilization Technology and Child Health (2020) : https://ncbi.nlm.nih.gov/pmc/articles/PMC7026576/#:~:text=The%20risks%20of%20heart%20defects,but%20also%20on%20IVF%20itself.

prefer fruit and meat : https://www.chinahighlights.com/giant-panda/giantpanda-diet.htm

Both Angola and the Democratic Republic of the Congo Experiencing High Numbers of Agricultural Fires (2020) : https://www.nasa.gov/image-article/both-angola-democratic-republic-of-congo-experiencing-high-numbers-of-agricultural-fires/

### About oxydative stress

Melanin and facial skin fluorescence as markers of yellowish discoloration with aging (2009) : https://doi.org/10.1111/j.1600-0846.2009.00396.x

Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs (2016) : https://doi.org/10.1038/srep27848

### Fat storage of denatured molecules

Plasma advanced glycation end products are decreased in obese children compared with lean controls (2009) : https://doi.org/10.1080/17477160802248039

Fat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product, in Adults (2011) : https://doi.org/10.3945%2Fjn.111.143172

Obesity and Systemic Oxidative Stress, Clinical Correlates of Oxidative Stress in The Framingham Study (2003) : https://ahajournals.org/doi/abs/10.1161/01.ATV.0000058402.34138.11

Oxidative stress, AGE, and atherosclerosis (2007) : https://doi.org/10.1038/sj.ki.5002382

An Advanced Glycation End Product (AGE)-Receptor for AGEs (RAGE) Axis Restores Adipogenic Potential of Senescent Preadipocytes through Modulation of p53 Protein Function (2012) : https://pubmed.ncbi.nlm.nih.gov/23150674/

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice (2013) : https://pubmed.ncbi.nlm.nih.gov/23011593

Advanced Glycation End-products accelerate amyloid deposits in adipocyte's lipid droplets (2023) : https://doi.org/10.1101/2023.11.06.565836

Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance (2014) : https://doi.org/10.1161/ATVBAHA.113.302281

Adipokines Mediate Inflammation and Insulin Resistance (2013) : https://ncbi.nlm.nih.gov/pmc/articles/PMC3679475/

Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes‐related ventricular arrhythmogenesis (2022) : https://ncbi.nlm.nih.gov/pmc/articles/PMC9630757/

## Defining the natural diet

Snow Monkey diet, Minnesota Zoo : https://mnzoo.org/blog/animals/snow-monkey/

### About insects and meat

Aquatic versus savanna: comparative and paleo-environmental evidence : https://doi.org.1177/026010609300900304

Human gastric juice contains chitinase that can degrade chitin (2007) : https://doi.org/10.1159/000104144

What tree-climbing pygmies tell us about foot evolution, National-Geographic : https://nationalgeographic.com/science/article/what-tree-climbing-pygmies-tell-us-about-foot-evolution

The mammoth steppe: a high-productivity phenomenon (2012) : https://doi.org/10.1016/j.quascirev.2012.01.011

Glacial refugia: hotspots but not melting pots of genetic diversity (2009) : https://doi.org/10.1126/science.1158764

Quaternary refugia of European trees (2003) : https://doi.org/10.1046/j.1365-2699.2003.00930.x

Global hunter-gatherer population densities constrained by influence of seasonality on diet composition (2021) : https://nature.com/articles/s41559-021-01548-3

### Debunking justifications for cooking

apes are actively nocturnal : https://pubmed.ncbi.nlm.nih.gov/29417991/

Autofluorescence of experimentally heated bone: Potential archaeological applications and relevance for estimating degree of burning (2020) : https://doi.org/10.1016/j.jasrep.2020.102333

The Food Opiodes: Casomorphins and Gluteomorphins and Mental Health (2024) : https://www.drhagmeyer.com/the-food-opiods-casomorphins-and-gluteomorphins/

Mozambican Grass Seed Consumption During the Middle Stone Age (2009) : https://pnas.org/content/106/27/10966

Great apes prefer cooked food (2008) : https://doi.org/10.1016/j.jhevol.2008.03.003

## Effects of cooking

### On mind and body

Wheat Gluten as a Pathogenic Factor in Schizophrenia (1976) : https://doi.org/10.1126/science.1246624

Use of a Gluten-Free Diet in Schizophrenia: A Systematic Review (2018) : https://ncbi.nlm.nih.gov/pmc/articles/PMC6247287/

Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients (2013) : https://pubmed.ncbi.nlm.nih.gov/22516148/

Sugar-and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia (2017) : https://doi.org/10.1161/STROKEAHA.116.016027

Sugary beverage intake and preclinical Alzheimer's disease in the community (2017) : https://doi.org/10.1016/j.jalz.2017.01.024

Is Soda Bad for Your Brain? (And Is Diet Soda Worse?) : https://bu.edu/articles/2017/soda-bad-for-brain/

Cicatriser sous crudités (2021) : https://youtube.com/watch?v=-CkWmgL0k00

Consequences of a Long-Term Raw Food Diet on Body Weight and Menstruation: Results of a Questionnaire Survey (1998) : https://doi.org/10.1159/000012770

### On reproduction

Reproductive aging in captive and wild common chimpanzees: factors influencing the rate of follicular depletion : https://doi.org/10.1002/ajp.20650

Human Growth and Development in Basics in Human Evolution (2015) : https://doi.org/10.1016/B978-0-12-802652-6.00020-7

Breastfeeding and timing of pubertal onset in girls: a multiethnic population-based prospective cohort study (2019) : https://doi.org/10.1186/s12887-019-1661-x

Human growth and development among high-altitude populations in 'The Biology of high altitude peoples' (1978) : https://openlibrary.org/books/OL4904133M/The_Biology_of_high_altitude_peoples

First period tied to girl's weight, Reuters (2011) : https://reuters.com/article/us-first-period-tied-girl-weight-idUSTRE72G82J20110317

Why do humans – and so few other animals – have periods? (2020) : https://eusci.org.uk/2020/04/09/why-do-humans-and-so-few-other-animals-have-periods/

La révolution française aurait-elle contribué à avancer l'âge de la puberté des filles ? (2015) : https://doi.org/10.3917/ethn.154.0607

Oogenesis in adult mammals, including humans: a review (2005) : https://doi.org/10.1385/ENDO:26:3:301

Concerning female ejaculation and the female prostate (1978) : http://dx.doi.org/10.1080/00224497809550988

Neurons for Ejaculation and Factors Affecting Ejaculation (2022) : https://doi.org/10.3390/biology11050686

## A fallen world

### Manufactured baselines

Abnormal behaviors induced by chemical pollution: a review of the evidence and new challenges (2004) : https://doi.org/10.1016/j.anbehav.2004.01.005

bottom of the ocean : https://education.nationalgeographic.org/resource/plastic-bag-found-bottom-worlds-deepest-ocean-trench

### Diet and ecological context

Fruit-feeding and activity patterns of mountain gorillas (Gorilla beringei beringei) in Bwindi Impenetrable National Park, Uganda (2020) : https://doi.org/10.1002/ajpa.24056

Gorilla diet in the Lope Reserve, Gabon: a nutritional analysis (1990) : https://doi.org/10.1007/bf00329756

Dietary variability of western gorillas (Gorilla gorilla gorilla) (2022) : https://doi.org/10.1371/journal.pone.0271576

Diet of Grauer's Gorillas in the Montane Forest of Kahuzi, Democratic Republic of Congo (2005) : https://doi.org/10.1007/s10764-005-8856-8

Nutritional quality of gorilla diets: consequences of age, sex, and season (2008) : https://doi.org/10.1007/s00442-007-0901-1

17% : https://wildgorillasafaris.com/facts-about-gorilla-facts/how-much-does-a-gorilla-eat-per-day

Nutrition in Primates, last modification: 2022 : https://msdvetmanual.com/management-and-nutrition/nutrition-exotic-and-zoo-animals/nutrition-in-primates

### Health and lifespan

Skeletal and Dental Pathology of Free-Ranging Mountain Gorillas (G. b. beringei) (1990) : https://doi.org/10.1002/ajpa.1330810309

Favorable ecological circumstances promote life expectancy in chimpanzees similar to that of human hunter-gatherers (2017) : https://dx.doi.org/10.1016/j.jhevol.2017.01.003

Natural mortality and cause of death analysis of the captive chimpanzee: a 35 year review (2017) : https://doi.org/10.1111%2Fjmp.12267

Mortality rates among wild chimpanzees (2001) : https://doi.org/10.1006/jhev.2001.0469

Risk factors for respiratory illness in a community of wild chimpanzees (2018) : https://royalsocietypublishing.org/doi/10.1098/rsos.180840

conflict beginning in 2018 : https://doi.org/10.1007/s10329-019-00730-3

130,000 gorillas and chimpanzees since the 1990s : https://phys.org/news/2015-01-ebola-virus-population-chimps-gorillas.html

Recent loss of closed forests is associated with Ebola virus disease outbreaks (2017) : https://nature.com/articles/s41598-017-14727-9

Epidemics in Populations of Wild Ruminants: Anthrax and Impala, Rinderpest and Buffalo in Lake Manyara National Park, Tanzania (1997) : https://doi.org/10.2307/3565551

### Justifying wars

Chimpanzee violence is a serious topic: A response to Sussman and Marshack's critique of Demonic Males: Apes and the Origins of Human Violence : http://nonkilling.org/pdf/wp1.pdf

overestimated : https://newscientist.com/article/dn23895-vendettas-not-war-unpicking-why-our-ancestors-killed/

Anthropologist Brian Ferguson Challenges Claim that Chimp Violence is Adaptive (2014) : https://www.scientificamerican.com/blog/cross-check/anthropologist-brian-ferguson-challenges-claim-that-chimp-violence-is-adaptive/

Chimpanzees, War, and History: Are Men Born to Kill (2023) : https://doi.org/10.1093/oso/9780197506752.001.0001

6 Why the Legend of the Killer Ape Never Dies: The Enduring Power of Cultural Beliefs to Distort Our View of Human Nature (2013) : https://doi.org/10.1093/acprof:oso/9780199858996.003.0006

How primate research was hijacked by sexist ideologues (2022) : https://theatlantic.com/magazine/archive/2022/06/ape-gender-frans-de-waal-lucy-cooke/629637/

Extremely High Frequency of Promiscuous Mating of Female Chimpanzees Observed in the Kalinzu Forest, Uganda : https://www.researchgate.net/publication/250158232_Extremely_High_Frequency_of_Promiscuous_Mating_of_Female_Chimpanzees_Observed_in_the_Kalinzu_Forest_Uganda

### Justifying addictions

Chronic intake of fermented floral nectar by wild treeshrews (2008) : https://pmc.ncbi.nlm.nih.gov/articles/PMC2492458/

<strong>processed pellets and bread</strong> : https://doi.org/10.1016/0031-9384(90)90077-h

gastric relief : https://dx.doi.org/10.1136/jim-2020-001436

plastic recipient : https://doi.org/10.1098/rsos.150150

structurally identical to that of drugs : https://theguardian.com/society/2017/aug/25/is-sugar-really-as-addictive-as-cocaine-scientists-row-over-effect-on-body-and-brain

varies by a factor of 23 across passerine species : https://lintulehti.birdlife.fi:8443/pdf/artikkelit/778/tiedosto/of_60_2-9_artikkelit_778.pdf

conflicting : https://doi.org/10.1007/s10336-012-0858-7

results : https://pubmed.ncbi.nlm.nih.gov/2369387/

more careful analyses : https://eastbaytimes.com/2009/12/24/gary-bogue-drunk-robins-its-a-myth-that-those-birds-are-drunk-on-berries/

## Modern confirmations

43% of cognitively healthy people aged 80–89 : https://doi.org/10.1001/jamaneurol.2018.2876

a third of all cognitively normal people over 70 : https://pmc.ncbi.nlm.nih.gov/articles/PMC4486209/

abundant plaques and full cognitive integrity : https://pmc.ncbi.nlm.nih.gov/articles/PMC3234452/

produced no reliable cognitive benefit : https://arxiv.org/pdf/2310.15456

caused patients to worsen : https://www.uc.edu/news/articles/2022/09/decreased-proteins-not-amyloid-plaques-tied-to-alzheimers.html

correlate far more tightly with <strong>neuronal loss</strong> and symptoms : https://jnm.snmjournals.org/content/63/6/830