## The Out-Of-Africa nonsense Construction of Indian human brain atlas (2019) : https://doi.org/10.4103/0028-3886.253639 Blackhenge: Debunking the Media misinterpretation of the Stonehenge Builders (2025) : https://prehistoric-britain.co.uk/blackhenge-debunking-the-media-misinterpretation-of-the-stonehenge-builders Spanish study : https://pubmed.ncbi.nlm.nih.gov/24463515/ ### False mitochondrial Eve Coalescent theory, Wikipedia : https://en.wikipedia.org/wiki/Coalescent_theory Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females (2013) : https://doi.org/10.1126/science.1237619 The Simons Genome Diversity Project: 300 genomes from 142 diverse populations (2016) : https://doi.org/10.1038/nature18964 The Eve Hypotheses: A Genetic Critique and Reanalysis (1993) : https://jstor.org/stable/681179 Phylogenetic congruence, conflict and consilience between molecular and morphological data (2023) : https://doi.org/10.1186/s12862-023-02131-z Dates from the molecular clock: how wrong can we be? (2006) : https://doi.org/10.1016/j.tree.2006.11.013 The maximum genetic diversity theory: a comprehensive framework for understanding evolutionary processes (2025) : https://doi.org/10.2478/biocosmos-2025-0009 Inverse relationship between genetic diversity and epigenetic complexity (2009) : https://doi.org/10.1038/npre.2009.1751.2 Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA (2019) : http://dx.doi.org/10.1101/101410 Neandertal DNA and modern humans (2008) : https://creationresearch.org/crsq-2009-volume-45-number-4_neandertal-dna-and-modern-humans The Neandertal mitochondrial genome does not support evolution (2009) : https://creation.com/neandertal-mitochondrial-genome ### Explaning away the bigger brain New insights into differences in brain organization between Neanderthals and anatomically modern humans (2013) : https://doi.org/10.1098/rspb.2013.0168 Latitudinal variation in light levels drives human visual system size (2011) : https://doi.org/10.1098/rsbl.2011.0570 Latitudinal variation in light levels drives human visual system size, supplementary materials : https://royalsocietypublishing.org/action/downloadSupplement?doi=10.1098%2Frsbl.2011.0570&file=rsbl20110570supp1.pdf Visual Cortex in Humans (2008) : https://spinozacentre.nl/dumoulin/PDFs/Wandell-Encyclopedia-2009.pdf Is baseline pupil size related to cognitive ability? Yes (under proper lighting conditions) (2021) : https://doi.org/10.1016/j.cognition.2021.104643 The evolutionary mystery of gigantic human brains (2018) : https://arstechnica.com/science/2018/08/the-evolutionary-mystery-of-gigantic-human-brains/ ### Antiracist conspiracy A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) : https://nature.com/articles/s41598-019-44877-x ## We, Neanderthals ### Cooking and neoteny The Tabun Cave and Paleolithic Man in the Levant (1982) : https://www.jstor.org/stable/1689660 Genomic structure in Europeans dating back at least 36,200 years (2014) : https://doi.org/10.1126/science.aaa0114 Mean Intracranial Volume of Brain among Patients with Normal Magnetic Resonance Imaging Referred to the Department of Radiology and Imaging of a Tertiary Care Centre (2023) : https://pmc.ncbi.nlm.nih.gov/articles/PMC10792718/ Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (2019) : https://doi.org/10.1186/s13195-019-0506-z 7.2 million-Year-Old Pre-Human Fossil A Challenge to Out of Africa? (2020) : https://ancient-origins.net/human-origins-science/mankind-arose-europe-not-africa-021987 Hominin presence in Eurasia by at least 1.95 million years ago (2025) : https://www.nature.com/articles/s41467-025-56154-9 Semicircular canals shed light on bottleneck events in the evolution of the Neanderthal clade (2024) : https://doi.org/10.1038/s41467-025-56155-8 ### Autodomestication through cooking Variation in cross-sectional indicator of femoral robusticity in Homo sapiens and Neandertals (2022) : https://doi.org/10.1038/s41598-022-08405-8 A journey to the golden age, 2. Glaciations and migration, hybridization, and survival (en) : https://mariecachet.wordpress.com/2012/09/26/2-glaciations-and-migration-hybridization-and-survival-en/ What Happens to the Craniofacial Structure of Humans Who Live Past 100 Years? Neanderthal Similarities (1998) : https://digitalcommons.cedarville.edu/icc_proceedings/vol4/iss1/12 ### The start of cooking New Data on the Late Neandertals: Direct Dating of the Belgian Spy Fossils (2025) : https://research.rug.nl/files/6730585/2009AmJPhysAnthropolSemal.pdf Earliest modern human genomes constrain timing of Neanderthal admixture (2024) : https://nature.com/articles/s41586-024-08420-x ### Reconstructions and lies Una nuova approssimazione facciale per l’Uomo de la Chapelle-aux-Saints 1 (2023) : https://doi.org/10.13140/RG.2.2.33164.08326 A Race-By-Race Breakdown of Human Genetic Diversity: Illustrated Guide for Novices, Thuletide (2022) : https://thuletide.wordpress.com/2020/06/29/a-race-by-race-breakdown-of-human-genetic-diversity-illustrated-guide-for-novices/ ### Twice our strength How Strong were the Neandertals? Leverage and Muscularity at the Shoulder and Elbow in Mousterian (2006) : https://academia.edu/1439962/How_strong_were_the_Neandertals_Leverage_and_muscularity_at_the_shoulder_and_elbow_in_Mousterian_foragers The shanidar neanderthals, p.43 (1983) : https://openlibrary.org/books/OL3160759M/The_Shanidar_Neandertals Cheap labor: myosin fiber type expression and enzyme activity in the forelimb musculature of sloths (Pilosa: Xenarthra) (2018) : https://doi.org/10.1152/japplphysiol.01118.2017 Neandertal energetics: Uncertainty in body mass estimation limits comparisons with Homo sapiens (2015) : https://doi.org/10.1016/j.jhevol.2015.04.007 Femoral curvature in Neanderthals and modern humans: A 3D geometric morphometric analysis (2011) : https://doi.org/10.1016/j.jhevol.2010.09.009 ## Lifespan and ontogeny ### Ape or age ? Supraorbital morphology and social dynamics in human evolution (2018) : https://doi.org/10.1038/s41559-018-0528-0 Masticatory Loading and Bone Adaptation in the Supraorbital Torus of Developing Macaques (2009) : https://doi.org/0.1002/ajpa.20972 The Supraorbital Torus: a most Remarkable peculiarity [and Comments and Replies] (1985) : http://jstor.org/stable/2742733 A Geographic Cline of Skull and Brain Morphology among Individuals of European Ancestry (2011) : https://doi.org/10.1159/000330168 The evolution of cranial form in mid-Pleistocene Homo (2012) : http://dx.doi.org/10.4102/sajs.v108i3/4.719 Origins and evolution of extreme lifespan in Pacific Ocean rockfishes (2021) : https://pmc.ncbi.nlm.nih.gov/articles/PMC8923369/ Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation (2023) : https://www.science.org/doi/10.1126/sciadv.add2743 Somatic mutation as an explanation for epigenetic aging (2025) : https://doi.org/10.1038/s43587-024-00794-x Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations (2024) : https://doi.org/10.1016/j.arr.2024.102268 On aging and age-specific effects of spontaneous mutations (2023) : https://academic.oup.com/evolut/article/77/8/1780/7169332 A Theory of Age-Dependent Mutation and Senescence (2008) : https://pmc.ncbi.nlm.nih.gov/articles/PMC2516080/ Empirical verification of evolutionary theories of aging (2016) : https://aging-us.com/article/101090/text The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence (2020) : https://pmc.ncbi.nlm.nih.gov/articles/PMC7403645/ ### Neanderthals and cooking Neanderthal Medics? Evidence for Food, Cooking, and Medicinal Plants Entrapped in Dental Calculus (2012) : https://doi.org/10.1007/s00114-012-0942-0 Midden or Molehill: The Role of Coastal Adaptations in Human Evolution and Dispersal (2019) : https://doi.org/10.1371/journal.pone.0186684 A Neandertal dietary conundrum: Insights provided by tooth enamel Zn isotopes from Gabasa, Spain (2017) : https://doi.org/10.1073/pnas.2109315119 Exceptionally high δ15N values in collagen single amino acids confirm Neandertals as high-trophic level carnivores (2019) : https://doi.org/10.1073/pnas.1814087116 Body size predicts ontogenetic nitrogen stable-isotope (δ15N) variation, but has little relationship with trophic level in ectotherm vertebrate predators (2024) : https://doi.org/10.1038/s41598-024-61969-5 The diet-body offset in human nitrogen isotopic values: A controlled dietary study (2012) : https://doi.org/10.1002/ajpa.22140 Nitrogen isotope fractionation in a continuous culture system containing phytoplankton and blue mussels (2019) : https://pmc.ncbi.nlm.nih.gov/articles/PMC7036703/ A new era of isotope ecology: Nitrogen isotope ratio of amino acids as an approach for unraveling modern and ancient food web (2023) : https://doi.org/10.2183/pjab.99.009 Isotopic Nitrogen-15 Labeling of Mice Identified Long-lived Proteins of the Renal Basement Membranes (2020) : https://doi.org/10.1038/s41598-020-62348-6 Can heavy isotopes increase lifespan? Studies of relative abundance in various organisms reveal chemical perspectives on aging (2016) : https://pmc.ncbi.nlm.nih.gov/articles/PMC5108472/ Australopithecus at Sterkfontein did not consume substantial mammalian meat (2025) : https://doi.org/10.1126/science.adq7315 Putrid Meat and Fish in the Eurasian Middle and Upper Paleolithic: Are We Missing a Key Part of Neanderthal and Modern Human Diet (2017) : https://www.paleoanthro.org/media/journal/content/PA20170044.pdf Alternatives to Neanderthal Hypercarnivory — Experimental Study of the δ15N Values of Meat During Putrefaction : https://ui.adsabs.harvard.edu/abs/2018AGUFM.B53K2204F/ ## Antediluvian civilizations Yangshan monument : https://youtube.com/watch?v=SP5RwRkkn2k&list=PL92SXkFO15Cyy2_UEApzB0ghgR5fcDOsT technology surpassing any historical culture : https://youtube.com/watch?v=BTd1fRCAvR4 misrepresentation and dishonesty : https://youtube.com/watch?v=XzDbhVDlhjU&t=3s&ab_channel=DeDunking precise parallel marks : https://youtube.com/watch?v=PCgdVAHsQ_w The Thunder Stone: from 1,500 down to 400 tons, Jiri Mruzek : https://grahamhancock.com/phorum/read.php?1,1049641,1049641 Baalbek megaliths : http://vejprty.com/baalbek.htm precision stands wholly apart : https://unchartedx.com/site/2026/05/20/precise-vases-are-fakes-again/ metal microparticle inclusions including titanium : https://youtube.com/watch?v=bkrmM_AlryQ by centuries : https://youtube.com/watch?v=UgLuLd_4B18 more stone blocks than all other dynasties combined : https://academia.edu/45014007/15_Reasons_why_Khufu_did_NOT_build_the_Great_Pyramid impossible to replicate today : https://youtube.com/@andeanmegalithictechnology3525 Younger Dryas Boundary : https://cosmictusk.com/category/younger-dryas-impact-evidence/ ### Addressing the standard objections Peru and the Sacred Valley : https://youtube.com/watch?v=oxuiB1vhDjM&list=PLb1MDIWaJM6nDgVIUbIOlIaUK4znWK-Fy microstructure of the Great Pyramid’s limestone blocks : https://doi.org/10.1111/j.1551-2916.2006.01308.x geopolymer casting : https://geopolymer.org/archaeology/pyramids/pyramids-2-the-evidences/ deep overcuts : https://youtu.be/ixTTvRGk0HQ?t=3183 manufactured stones : https://youtube.com/watch?v=QJWmZVhI_K4&ab_channel=AndeanMegalithicTechnology power tools : https://youtube.com/watch?v=d8Ejf5etV5U Ancient Quarry Mount Nokogiri Excavated by Prehistoric Machines or Hand Tools? : https://youtube.com/watch?v=5kq8CFI7WXQ ### Beginning and end of an era Younger Dryas Boundary : https://cosmictusk.com/category/younger-dryas-impact-evidence/ 9% of Earth’s surface biomass : https://doi.org/10.1086/695704 ## Gods of Legends ### Language of Babel Translucency Ratings of Blissymbols over Repeated Exposures by Children with Autism (2013) : https://doi.org/10.3109/07434618.2013.813967 Transparency of Three Communication Symbol Systems (1984) : https://doi.org/10.1044/jshr.2703.436 Language and Experience Evidence from the Blind Child, Barbara Landau, Lila R. Gleitman : https://psycnet.apa.org/record/1985-97756-000 Shared understanding of color among sighted and blind adults (2O21) : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379969/ Genic control of honey bee dance language dialect (1995) : https://doi.org/10.1007/bf00220950 Adaptive evolution of honeybee dance dialects (2020) : https://doi.org/10.1098/rspb.2020.0190 2008, East Learns from West: Asiatic Honeybees Can Understand Dance Language of European Honeybees : https://doi.org/10.1371/journal.pone.0002365 The Behavioral Ecology of Insect Vibrational Communication (2005) : https://doi.org/10.1641/0006-3568(2005)055[0323:tbeoiv]2.0.co;2 Sensory evidence for complex communication and advanced sociality in early ants (2024) : https://www.science.org/doi/10.1126/sciadv.adp3623 How Do Ants Communicate: Understanding the Complex Language of Ants in Dallas-Fort Worth : https://forterrapestcontrol.com/blog/how-do-ants-communicate-understanding-the-complex-language-of-ants-in-dallas-fort-worth Differences in acoustic features of vocalizations produced by killer whales cross-socialized with bottlenose dolphins featured (2014) : https://doi.org/10.1121/1.4893906 Recursive sequence generation in crows (2022) : https://doi.org/10.1126/sciadv.abq3356 Recursive syntactic pattern learning by songbirds (2006) : https://doi.org/10.1038/nature04675 Exploring the linguistic capacities of bottlenose dolphins: the processing of recursive syntax : https://the-pttrn.nl/static/pdf/Exploring-the-linguistic-capacities-of-bottlenose-dolphins.pdf mindless Chinese room : https://en.wikipedia.org/wiki/Chinese_room The tongue of the Angels : https://www.theosophical.org/publications/quest-magazine/4114-the-tongue-of-angels ## The laws of heredity ### The core debate: Darwinism versus Lamarckism The maximum genetic diversity theory: a comprehensive framework for understanding evolutionary processes (2025) : https://doi.org/10.2478/biocosmos-2025-0009 ### Mendel’s laws and their limits QTL : https://en.wikipedia.org/wiki/Quantitative_trait_locus Evidence of evolutionary forces leading to the spread of lethal genes in wild population of house mice (1957) : https://doi.org/10.1073/pnas.43.1.158 ### The quantal structure of DNA Multi-SNP Analysis of MHC Region: Remarkable Conservation of HLA-A1-B8-DR3 Haplotype (2006) : https://doi.org/10.2337/db05-1276 Commentary: Conserved polymorphic sequences protect themselves for future challenges (2022) : https://doi.org/10.3389/fgene.2022.993944 Speciation of Genes and Genomes: Conservation of DNA Polymorphism by Barriers to Recombination Raised by Mismatch Repair System (2022) : https://doi.org/10.3389/fgene.2022.803690 Analysis of Haplotype Sequences (2015) : https://doi.org/10.5772/61794 Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms (2011) : https://doi.org/10.1016/j.humimm.2010.12.005 Major Histocompatibility Complex (MHC) in Health and Disease (2020) : https://mdpi.com/books/reprint/2011-major-histocompatibility-complex-mhc-in-health-and-disease Genomic evolution in domestic cattle: Ancestral haplotypes and healthy beef (2011) : https://doi.org/10.1016/j.ygeno.2011.02.006 ### Endogenous, intelligent adaptations Soma to germline inheritance of extrachromosomal genetic information via a LINE-1 reverse transcriptase-based mechanism (2016) : https://doi.org/10.1002/bies.201500197 Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes (2014) : https://doi.org/10.1371/journal.pone.0101629 Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC: The manifest polymorphism of the MHC appears greatly exceeded at Immunoglobulin loci, suggesting antigen-selected somatic V mutants penetrate Weismann's Barrier (2015) : https://europepmc.org/article/MED/25810320 Somatic mutation patterns at Ig and Non-Ig Loci (2024) : https://doi.org/10.1016/j.dnarep.2023.103607 Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR (2019) : https://doi.org/10.1111%2Fsji.12853 Germline V repertoires: Origin, maintenance, diversification, Steele, E. J., & Lindley, R. A. (2018) : https://doi.org/10.1111/sji.12670 Stress responses and genetic variation in bacteria (2004) : https://doi.org/10.1016/j.mrfmmm.2004.07.017 Gene conversion-like events in the diversification of human rearranged IGHV3-2301 gene sequences : https://doi.org/10.3389/fimmu.2012.00158 Heterozygosity of H–2 loci in wild mice (1979) : https://doi.org/10.1038/281603a0 What evolutionary processes maintain MHC IIꞵ diversity within and among populations of stickleback? (2021) : https://doi.org/10.1111/mec.15840 The importance of immune gene variability (MHC) in evolutionary ecology and conservation (2005) : https://doi.org/10.1186/1742-9994-2-16 Molecular Lamarckism: on the evolution of human intelligence (2017) : https://doi.org/10.1080/02604027.2017.1319669 ### Transmission Ratio Distortion Standard Deviations: The Biological Bases of Transmission Ratio Distortion (2019) : https://doi.org/10.1146/annurev-genet-112618-043905 Evaluating the Evidence for Transmission Distortion in Human Pedigrees (2012) : https://doi.org/10.1534/genetics.112.139576 Evidence for Extensive Transmission Distortion in the Human Genome (2004) : https://doi.org/10.1086/381131 Selfish genetic elements (2018) : https://doi.org/10.1371/journal.pgen.1007700 Drive and sperm the evolution and genetics of male meiotic drive (2009) : https://doi.org/10.1016/B978-0-12-372568-4.00012-4 Transmission ratio distortion: review of concept and implications for genetic association studies (2013) : https://doi.org/10.1007/s00439-012-1257-0 The Ecology and Evolutionary Dynamics of Meiotic Drive : http://dx.doi.org/10.1016/j.tree.2016.02.001 Within-Ejaculate Sperm Selection and Its Implications for Assisted Reproduction Technologies (2021) : https://doi.org/10.1007/978-3-030-66292-9_20 Do sperm possess a molecular passport? Mechanistic insights into sperm selection in the female reproductive tract (2015) : https://doi.org/10.1093/molehr/gav012 The role of the tumor suppressor p53 in spermatogenesis (1998) : https://doi.org/10.1038/sj.cdd.4400396 Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes (2018) : https://doi.org/10.1111/evo.13591 The Magic That Happens When a Sperm Meets an Egg and the Sparks Fly : https://idahofertility.com/the-magic-that-happens-when-a-sperm-meets-an-egg-and-the-sparks-fly/ Haploid selection within a single ejaculate increases offspring fitness (2017) : https://doi.org/10.1073/pnas.1705601114 Chromatin-unstable boar spermatozoa have little chance of reaching oocytes in vivo (2018) : https://doi.org/10.1530/rep-07-0333 Cryptic female choice - Wikipedia : https://en.wikipedia.org/wiki/Cryptic_female_choice Male transmission ratio distortion supports MHC-linked cryptic female choice in the lesser kestrel (Aves: Falconidae) (2012) : https://doi.org/10.1007/s00265-012-1401-9 Sperm variation within a single ejaculate affects offspring development in Atlantic salmon (2014) : https://ncbi.nlm.nih.gov/pmc/articles/PMC3949374/ L26/O-321 Molecular signatures of sperm-level selection in humans (2026) : https://academic.oup.com/humrep/article/41/Supplement_1/deag083.319/8727344 Exosomes and exosomal non‑coding RNAs throughout human gestation (2022) : https://doi.org/10.3892/etm.2022.11518 Lamarck and Panspermia, On the Efficient Spread of Living Systems Throughout the Cosmos (2019) : https://doi.org/10.1016/j.pbiomolbio.2019.08.010 Crossovers are associated with mutation and biased gene conversion at recombination hotspots (2014) : https://doi.org/10.1073/pnas.1416622112 Male Microchimerism in the Human Female Brain (2012) : https://doi.org/10.1371/journal.pone.0045592 ### Fixity versus fluidity genetic hitchhiking : https://en.wikipedia.org/wiki/Genetic_hitchhiking To Supplement or Not to Supplement: Are Inuit Getting Enough Vitamin D? (2019) : https://erudit.org/en/journals/etudinuit/2016-v40-n2-etudinuit04225/1055442ar/ ## Renewal through inbreeding ### In defense of inbreeding Studies on inbreeding, I. The effects of inbreeding on the growth and variability in the body weight of the albino rat (1918) : https://doi.org/10.1002/jez.1400260102 Inbreeding Effects on Layer Performance at Two Levels of Protein Intake (1980) : https://doi.org/10.3382/ps.0591155 Phylo Metabolomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice (2008) : https://doi.org/10.1371/journal.pone.0001668 Effect of diet on spontaneous disease in the inbred mouse strain C57B1/10J (1985) : https://doi.org/10.1016/0378-4274(85)90072-4 Influence of heredity on response of inbred rats to diet: I. Differences in body size, food intakes, incidence of spontaneous kidney defects, kidney weights, urine pH and protein (1967) : https://doi.org/10.1016/0026-0495(67)90027-3 Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice (2021) : https://doi.org/10.1111/acel.13500 extremely consanguineous : https://doi.org/10.1038/s41598-019-38571-1 Inbreeding, Incest, And The Incest Taboo The State of Knowledge at the Turn of the Century, from Arthur P. Wolf : https://holocausthandbooks.com/book/lectures-on-the-holocaust/ The Incest Taboo and the Mating Patterns of Animals (1963) : https://jstor.org/stable/667441 Inbreeding and broodstock management, FAO : https://fao.org/4/x3840e/X3840E00.htm ### Cousin marriage An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) : https://doi.org/10.1534%2Fgenetics.114.173351 Inbreeding Coefficient (2016) : https://link.springer.com/referenceworkentry/10.1007/978-1-4020-6754-9_8397 The effect of reproductive compensation on recessive disorders within consanguineous human populations (2002) : https://doi.org/10.1038/sj/hdy/6800090 ### Modeling inbreeding depression The effect of inbreeding rate on fitness, inbreeding depression and heterosis over a range of inbreeding coefficients (2014) : https://doi.org/10.1111%2Feva.12145 Local adaptation, coadaptation and population boundaries (1986) : https://doi.org/10.1002/zoo.1430050206 Elimination of inbreeding depression in a captive herd of Speke's gazelle (1984) : https://doi.org/10.1002/zoo.143003032 Mutation rate variability as a driving force in adaptive evolution (2019) : https://doi.org/10.1103%2FPhysRevE.99.022424 Mutation Patterns in the Human Genome: More Variable Than Expected (2009) : https://doi.org/10.1371/journal.pbio.1000028 Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome (2020) : https://doi.org/10.1038/s41467-020-15185-0 Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges (2022) : https://doi.org/10.1038/s41467-022-32353-6 Erratic mitochondrial clock variations of mutation rate, not population size, affect mtDNA diversity across birds and mammals (2009) : https://doi.org/10.1186/1471-2148-9-54 Mutations Beget More Mutations-Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation (2020) : https://pubmed.ncbi.nlm.nih.gov/31778175/ Phenotype of the Cyp1a1/1a2/1b1(−/−) Triple-Knockout Mouse (2009) : https://doi.org/10.1124/mol.108.045658 Inbreeding Depression in the Speke’s Gazelle Captive Breeding Program (1999) : https://montana.edu/kalinowski/documents/2000_Spekes_gazelle_inbreeding_ConservationBiology.pdf Pseudogenes: Pseudo-functional or key regulators in health and disease? (2011) : https://ncbi.nlm.nih.gov/pmc/articles/PMC3078729/ ### A case against heterotic selection Monomorphism and polymorphism at Mhc DRB loci in domestic and wild ruminants (1999) : https://doi.org/10.1111/j.1600-065x.1999.tb01390.x Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding (2015) : https://doi.org/10.1126/science.aaa3952 High MHC diversity confers no advantage for phenotypic quality and reproductive performance in a wild bird (2022) : https://doi.org/10.1111%2F1365-2656.13737 How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings (2010) : https://doi.org/10.1098/rspb.2009.2084 Understanding the relationship between the inbreeding coefficient and multilocus heterozygosity, theoretical expectations and empirical data (2004) : https://doi.org/10.1038/sj.hdy.6800485 Natural Selection Resisting Inbreeding Depression in Captive Wild House Mice (1979) : https://doi.org/10.2307/2407656 Genomic consequences of intensive inbreeding in an isolated wolf population (2017) : https://nature.com/articles/s41559-017-0375-4 Heterozygosity-fitness correlations and their relevance to studies on inbreeding depression in threatened species (2008) : https://doi.org/10.1111/j.1365-294x.2008.03910.x Do infectious diseases drive MHC diversity ? (2000) : https://doi.org/10.1016/s1286-4579(00)01287-9 MHC heterozygosity and survival in red junglefowl (2010) : https://doi.org/10.1111/j.1365-294x.2010.04724.x Genetic architecture and lifetime dynamics of inbreeding depression in a wild animal (2021) : https://doi.org/10.1038/s41467-021-23222-9 Sperm competition in birds: the role of male–female interactions, Birkhead & Fletcher (1995) : https://doi.org/10.1530/ROR.0.0030123 Sperm competition in insects: mechanisms and the potential for selection, Simmons & Siva-Jothy (1998) : https://doi.org/10.1098/rspb.1998.0494 Mate choice and genetic quality in birds, Kempenaers et al. (2007) : https://doi.org/10.1016/S0065-3454(07)37005-8 Postmating Female Control: 20 Years of Cryptic Female Choice, Renée C. Firman & al (2017) : https://doi.org/10.1016/j.tree.2017.02.010 Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for allele-specific measures (2003) : https://doi.org/10.1186/1471-2350-4-2 MHC heterozygosity confers a selective advantage against multiple-strain infections (2002) : https://doi.org/10.1073.pnas.162006499 The genetics of inbreeding depression (2009) : http://dx.doi.org/10.1038/nrg2664 ### What numbers actually tell Genetic Counseling and Screening of Consanguineous Couples and Their Offspring: Recommendations of the National Society of Genetic Counselors : https://doi.org/10.1023/a:1014593404915 The Consanguinamory Reproduction Study… The results are in! : https://consanguinamory.wordpress.com/2018/09/12/the-consanguinamory-reproduction-study-the-results-are-in/ ### Toward a selective breeding plan The HLA-B57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control (2023) : https://doi.org/10.3389%2Ffimmu.2023.1305856 MHC Genomics and Disease: Looking Back to Go Forward (2019) : https://doi.org/10.3390/cells8090944 Myasthenia gravis and HLA antigens in American blacks and other races (1984) : https://doi.org/10.1016/s0165-5728(84)80012-0 Prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido-Ekiti, Southwestern Nigeria (2023) : https://doi.org/10.1371%2Fjournal.pone.0280981 Abdominal Status and Blood Meal Preference of Anopheles Gambiae Complexes in Some Communities of Dutse Local government Area, Northwestern Nigeria (2023) : https://doi.org/10.4314/dujopas.v9i3b.2 Mosquitoes are not the major culprits for the high burden of malaria in Nigeria: a commentary (2020) : https://doi.org/10.11604%2Fpamj.2020.35.11.16972